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"The Burden of Proof" is the 958th episode of Holby City and the third episode of the 21st series. It was preceded by "China Crisis" and followed by "A Daring Adventure or Nothing at All". The episode was directed by Ian Barnes and written by Gerard Sampaio.

This episode features the guest appearance of Lola Griffin, portrayed by Sharon D Clarke, who last appeared as a series regular during the show's 10th series.

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