This article covers a subject that is part of the real world, and thus should not be taken as a part of the Holby universe.
This article contains plot details about an upcoming episode.
Series 21 is the 21st series of Holby City. It commenced airing on 2 January 2019. The series will comprise 53 episodes - an increase from the previous series. The 45th episode will be the show's 1000th overall.
In February 2019, it was revealed that the 10th episode of the series would be the second part of a two-part crossover with sister show Casualty - the first since December 2005.
In September, it was revealed that Camilla Arfwedson would reprise her role as cardiothoracic specialist registrar Zosia March for an extended guest stint in March. She last appeared in the series 20 episode "The Prisoner" after making her final appearance as a main character in September 2017. She will return on 19 February.
In November, it was announced that Jack Ryder would join the series on a recurring basis as consultant Evan Crowhurst, the boyfriend of registrar and fellow newcomer Chloe Godard. Later that month, it was also announced that Daisy Wood-Davis would make an appearance as Evan's sister Phoebe Crowhurst; the episode she features in will air in spring.
In December, Tom Campbell-Gore's guest appearance was officially announced, as well as the news that Sharon D Clarke would reprise her role as Lola Griffin for one episode as part of the show's 20th anniversary. The show's winter trailer also revealed the returns of Carole Copeland, Patricia Ghraoui and Roman Makarenko, portrayed by Julia Deakin, Sirine Saba and Marko Leht respectively. . Roman, Frieda Petrenko's former boyfriend, returned in episode 4. Carole, Dominic Copeland's mother, reappeared three weeks later in episode 7. Patricia will reappear in episode 9.Simon Harper confirmed that he was in talks with other former cast members about reappearing in the series. Debbie Chazen also revealed, via her Twitter account, that she would return to the series as obstetrician Fleur Fanshawe in a future episode.
On 15 February, it was announced that two crossover episodes between Holby City and its sister show Casualty would air in March. In the second part, which will air in Holby City's time slot, nine Casualty regulars will make guest appearances, including former Holby City character Connie Beauchamp, portrayed by Amanda Mealing. In the same episode, Francesca Barrett and Naomi Katiyo will reprise their roles as Beka Levy and Darla Johnstone respectively.